Senior Scientist Protein, Biochemical & Biophysical Sciences Expert
Location: Leuven
Job Type: Full-time
About Us: Onco3R is a dynamic and innovative biotech start-up company committed to transform patient’s lives with best-in-class medicines. We are seeking a highly skilled and motivated individual to join our team as Protein, Biochemical & Biophysical Sciences Expert.
Job Summary
We are seeking a Biochemistry & Biophysics Expert to help drive our discovery engine. This role is foundational to our scientific strategy, with a focus on characterizing molecular interactions, protein structure-function relationships, and supporting the development of novel therapeutic candidates.
Key Responsibilities
Design and perform biochemical and biophysical assays to characterize protein structure, stability, binding and function in the context of drug discovery projects.
Establish and optimize core biophysical platforms (e.g., SPR, DSF, MST) to support lead optimization, and mechanism-of-action studies.
Oversee protein expression, purification, and analytical characterization workflows.
Coordinate and manage relationships with CROs and academic collaborators to ensure high-quality, timely data delivery.
Collaborate with both internal and external structural biology and computational teams to interpret data in the context of 3D structure and guide rational design.
Work closely with protein engineering, cell biology, and translational teams to integrate biophysical insights into therapeutic development.
Analyze complex datasets, generate high-quality reports, and present findings to internal teams and external partners.
Contribute to scientific strategy, platform development, and IP generation in a fast-paced, entrepreneurial environment.
Job requirements
Ph.D. in Biochemistry, Biophysics, Structural Biology, or related field with 5–10+ years of relevant experience (industry or postdoc).
Deep expertise in biophysical techniques and quantitative analysis of molecular interactions.
Hands-on experience with protein purification and characterization.
Exposure to structural biology techniques (e.g., cryo-EM, X-ray crystallography, NMR) is a must.
Experience in managing relationships with CROs and academic collaborations is a plus.
Strong problem-solving skills and ability to work independently in a start-up setting.
Excellent communication and collaboration skills.
Benefits
Competitive salary and benefits package.
Opportunity to work in a fast-paced and innovative environment.
Opportunity to help shape the growth of the company.
How to Apply
Interested candidates should submit their resume to contact@onco3R.com